Creative playful design like the ones below are good for websites that don't require a great deal of pages or complicated applications. The home pages usually feature one or or more flash animations and navigates to several pages of similar design. Designs like these meet the needs of the artistic community, smaller cottage industries, restaurants and clubs.
The next set of styles are more of a magazine style. They are suited for websites with a magnitude of pages and applications. Usually the main navigation links open to sub-navigations. Designs like these are crisp and well organized for businesses and organizations that have a lot of data.
These examples work well for more conservative organizations and businesses. Usually they involve interactive forms, slightly complicated navigations and administrative applications. If you have a lot of content and expect a busy site with or without a shopping cart, a business style would suit your needs.